Saxenda vs. Wegovy: Which is Better?

GLP-1 medications have become a popular way to manage type 2 diabetes as well as lose weight, and Saxenda and Wegovy are two popular prescription medications. While both work by mimicking a hormone that helps regulate appetite and blood sugar, they differ in their active ingredients, dosing schedules, and overall effectiveness.

Whether you’re considering weight loss options or exploring alternatives to traditional diet plans, understanding the differences between these two popular weight loss medications can help you make a more informed decision with your doctor.

What Are GLP-1 Medications?

GLP-1 medications, also known as GLP-1 receptor agonists or GLP-1 RAs, are a drug class of injectable medications that mimic natural hormones called GLP-1s that your body produces whenever you eat. These GLP-1s help your body control blood sugar levels, assist in insulin production, and help with the feeling of satiety after you’ve eaten, which helps promote weight loss by increasing satiety and reducing hunger. GLP-1 RAs do all the same things that natural GLP-1s also do for your body.

Wegovy is an example of a GLP-1 medication, and it works by mimicking the GLP-1 hormone, which regulates appetite, delays stomach emptying, and influences brain regions responsible for hunger, thereby promoting weight loss.

GLP-1 medications were originally developed as a medication for type 2 diabetes, but over the past few years, they’ve also grown popular as injectable medications for weight loss. The demand for weight loss medications has gotten many drug manufacturers to produce weight loss variations of their type 2 diabetes medications to appeal to those markets and help preserve the diabetes medications for those who need them for those reasons.

There are several different active ingredients GLP-1 medications can use. Saxenda uses liraglutide as its active ingredient, and Wegovy uses semaglutide. Another popular active ingredient for GLP-1 RAs is tirzepatide.

What is Saxenda?

Saxenda is a daily weight loss injection. It was the first-ever GLP-1 RA medication to be approved for weight loss purposes rather than type 2 diabetes, and it was approved by the FDA in 2014. Saxenda is also approved for chronic weight management in adults with obesity or overweight conditions, often alongside lifestyle interventions such as diet and exercise. Saxenda is the weight loss medication variant of the type 2 diabetes medication Victoza. Both Saxenda and Victoza belong to the same drug class and are manufactured by Novo Nordisk, a Danish pharmaceutical company.

Saxenda is taken in increasing doses. Treatment begins with a low dose of 0.6 mg for the first week to minimize side effects, and the dosage is gradually increased. For the next three weeks, you increase the dosage size by 0.6 mg each week. So, the second week requires 1.2 mg, the third week requires 1.8 mg, and the fourth week requires 2.4 mg. On the fifth week, you increase the dosage to 3 mg and stay there without any further increases or decreases unless your doctor asks you to change your dosage size.

What is Wegovy?

Wegovy is a GLP-1 medication that is taken via injection once per week. It was FDA-approved in 2021 as a weight loss medication. The active ingredient in Wegovy is semaglutide, which is also used in other well-known medications like Ozempic and Rybelsus. However, whereas those medications are intended for managing diabetes symptoms, Wegovy is specifically approved for weight loss.

Wegovy is approved for long-term weight management in adults and children with a certain body mass index (BMI), making it an option for those who meet specific BMI thresholds for obesity treatment.

The dosage schedule for Wegovy starts at a base size of 0.25 mg for the first four weeks. After that, the dose is increased to 0.5 mg for the next four weeks, and then 1 mg for the next four weeks after that. The next four weeks use a dose of 1.7 mg, and this is where some people stop. However, if that isn’t enough to maintain weight loss, your doctor may increase your dose one last time to 2.4 mg. In clinical use, significant weight loss benefits have been observed, especially when Wegovy is combined with lifestyle changes such as diet and exercise.

Similarities Between Saxenda and Wegovy

There are some similarities between Saxenda and Wegovy. These include:

• Both medications are FDA-approved.
• Both medications can help you lose weight and treat obesity.
• Both medications are injectables that can be used on the stomach, thighs, or upper arms.
• Both medications are made by the same manufacturer, Novo Nordisk.
• Both medications have a lot of similar side effects, such as stomach pain, nausea, and constipation.
• Both medications are used for weight management in people with obesity or weight-related medical conditions, such as high blood pressure, high cholesterol, or type 2 diabetes.

Differences Between Saxenda and Wegovy

There are also a few key differences between the two prescription medications. These include:

• The active ingredient in Saxenda is liraglutide, while the active ingredient in Wegovy is semaglutide.
• Wegovy is a weekly injection, while Saxenda is a daily injection.
• Wegovy doses are smaller than Saxenda doses. Saxenda starts at 0.6 mg with a target dose of 3 mg, while Wegovy starts at 0.25 mg and has a target dose of 1.7 mg or 2.4 mg.
• Wegovy has been FDA-approved to help reduce the risk of major cardiovascular events like heart attack and stroke, and is the first weight loss medication approved to reduce the risk of cardiovascular disease in adults with obesity and known cardiovascular issues.
• The drug effects and side effect profiles differ between Saxenda and Wegovy. Both have potential serious risks, such as thyroid tumors and cancer (as noted in the FDA boxed warning), and may cause different side effects. Additionally, drug interactions can occur, especially with other oral medications such as those used for diabetes, so it is important to consult a healthcare professional before starting either medication.
• Individual health factors, such as existing medical conditions and overall health status, may influence which medication is more suitable. Patients should discuss their personal health factors with a healthcare provider to determine the best treatment option.

Saxenda vs Wegovy: Side Effects

Because Saxenda and Wegovy use different active ingredients, they have some different side effects. However, they still have a lot of similar side effects.

It is important to be aware that both medications can cause serious allergic reactions. Symptoms such as hives, swelling of the face, lips, or throat, trouble breathing, or difficulty breathing may indicate a severe allergic reaction and require immediate medical care. Allergic reactions, though rare, can be serious and should be closely monitored during treatment. Additionally, severe gastrointestinal issues may occur and also require prompt medical attention.

Similar Side Effects Between Wegovy and Saxenda

• Nausea
• Constipation
• Diarrhea
• Vomiting
• Headaches
• Burping
• Decreased appetite
• Fatigue
• Low blood sugar
• Dizziness
• Stomach pain
• Kidney problems

Different Side Effects Between Wegovy and Saxenda

Wegovy

When comparing Wegovy to Saxenda, Wegovy’s side effect profile includes several mild to moderate symptoms that users may encounter. These effects are typically manageable and may decrease over time as treatment progresses. Notable side effects include:

• Heartburn
• Stomach flu
• Runny nose
• Sore throat

Saxenda

Saxenda (liraglutide) presents a distinct set of side effects, with some variations between adult and teenage users. The medication’s side effect profile includes both common reactions at the injection site and some age-specific concerns worth noting. Key side effects include:

• Injection site reactions
• Fever (common in teens but not adults)
• Gastroenteritis, inflammation of the stomach and intestines (common in teens but not adults)
• Change in lipase levels in your blood

Effectiveness of Wegovy and Saxenda

In 2022, a clinical trial was held to test and compare the effectiveness of Wegovy and Saxenda. The study used 338 participants who combined using the medication with a healthy diet and exercise over the course of 68 weeks. When weight was compared between the two groups, those taking Wegovy lost significantly more than those taking Saxenda. Specifically, the clinical trial found that participants taking Wegovy reduced weight by an average of 17% of their body weight, while those taking Saxenda lost an average of 6.4%. This demonstrates how much weight can be lost with each medication, with Wegovy leading to more weight loss than Saxenda in the clinical trial.

The study also found that 13% of participants who took Wegovy discontinued the trial prematurely due to side effects, while 27.6% of the participants taking Saxenda did the same.

Overall, the study showed more significant weight loss from Wegovy as well as fewer side effects. However, each drug affects everyone differently, so this may not be representative of the experience you will have if you choose to take either drug.

Who Should Not Take Saxenda or Wegovy

Not every medication is going to be a good fit for every person, and GLP-1 medications can potentially have some severe side effects, especially in people who are already prone to certain conditions. People who should avoid taking medications like Saxenda or Wegovy include

• People with a personal or family history of thyroid cancer, including medullary thyroid carcinoma or MEN 2, due to the risk of thyroid tumors. Animal studies have suggested a potential link between these medications and thyroid tumors, and the FDA has issued a boxed warning regarding this risk.
• People who have had a severe allergic reaction to the active ingredients used in the medications
• People with a history of suicidal thoughts or behaviors or a history of self-harm
• Pregnant or breastfeeding women
• People who are planning to become pregnant within the next two months

Weight Loss Options for Children and Teens

Both Saxenda and Wegovy are approved for use in children ages 12 and up who are obese, while Saxenda specifically can be used for children as young as six years old. The dosage schedule is the same as it is for adults, but the maintenance dose is often lower in children and teens than it is in adults, and the appropriate dosage will be determined by the child’s doctor based on how they react to each increase.

The dosage schedule may also be slowed down to better accommodate the patient’s specific needs, which will also be determined by the patient’s doctor when developing an ideal treatment plan.

How to Access Medications

To access Saxenda or Wegovy, you’ll first need a prescription from a licensed healthcare provider like your primary care physician or another specialist you may see. It is important to consult a healthcare professional to ensure the safe and effective use of prescription drugs, as they can provide guidance on potential drug interactions, dosage adjustments, and overall safety. They’ll assess whether you meet eligibility criteria, review your medical history, and help you decide whether a GLP‑1 medication is right for you, whether it’s Saxenda, Wegovy, or another GLP-1 RA.

Once prescribed, you’ll fill it at a pharmacy. Many insurance plans require prior authorization for coverage, meaning your doctor submits paperwork to justify medical necessity. If you’re uninsured or your plan doesn’t cover the drug, manufacturer programs like NovoCare may offer savings or direct‑to‑consumer options.

Wegovy or Saxenda: Which is Right For You?

Both Wegovy and Saxenda offer effective support for weight loss when combined with healthy lifestyle changes. While they work in similar ways, their differences in dosing, ingredients, and side effects mean that one may suit your needs better than the other. The best choice depends on your health history, goals, and preferences, which is something a healthcare provider can help you evaluate.

If you’re unsure where to start your weight loss journey, consider signing up to speak with a registered dietitian at no cost to you. They can help you explore your options and create a personalized plan that works for your body and your life.

Saxenda vs Wegovy FAQ

Can Saxenda and Wegovy Affect Other Medications I’m Taking?

Because GLP‑1 RAs (especially those with longer action like Wegovy) slow how fast food leaves your stomach, they can change how quickly other medications are absorbed. This can matter especially for medications that need consistent absorption timing, like birth control and some thyroid medications.

Is There a Risk of Rebound Weight Gain After Discontinuing the Medication?

Like many weight loss medications, stopping Saxenda or Wegovy often results in weight regain unless lifestyle changes are maintained. These treatments are usually part of a long‑term plan, and discontinuation should be done under medical supervision.

Is it Possible to Switch Between Saxenda and Wegovy?

Yes, it is possible to switch between medications if you feel one is not working for you. When switching, your doctor will give you directions that may involve gradually reducing your dose until stopping the first medication or a short waiting period between the two medications. It’s important to follow your doctor’s instructions to avoid any negative effects that could be caused by taking the two drugs too close together.