Can Ozempic Cause Joint Pain?

Ozempic is a popular medication people can use to help manage their type 2 diabetes symptoms. Ozempic is typically prescribed as a second-line treatment (and in some cases as a third-line treatment) for type 2 diabetes when initial therapies like metformin are not sufficient. It is intended for adult patients with type 2 diabetes. The Canadian Agency for Drugs and Technologies in Health evaluates medications like Ozempic for use in Canada.

If you’ve just started taking Ozempic or are considering taking it and are concerned about joint pain, here is everything you should know about the links between Ozempic and joint pain so you can make an informed decision.

What is Ozempic?

Ozempic is a weekly injectable medication for type 2 diabetes that uses the drug semaglutide, a GLP-1 receptor agonist, as its active ingredient. While the drug is intended for type 2 diabetes, it can also be used off-label as a weight loss medication. And, in fact, Novo Nordisk produces another semaglutide medication specifically for weight loss called Wegovy.

Ozempic is a GLP-1 receptor agonist medication, meaning it mimics natural GLP-1 hormones that your body creates when you eat. These hormones promote feelings of fullness after eating, insulin secretion and production, and help reduce hunger to avoid overeating. Ozempic is prescribed to improve glycemic control in adult patients with type 2 diabetes. Ozempic has also been shown to help reduce the risk of major cardiovascular events and promote heart health. In addition to its use for weight loss, Ozempic is also used as part of a comprehensive weight management plan for some patients.

As an injectable medication, Ozempic may cause injection site reactions such as redness, swelling, or discomfort, and some people may experience pain at the injection site.

Like all medications, Ozempic can have adverse effects, which are discussed in the next section.

Ozempic Side Effects

Like any medication, Ozempic can come with side effects. The most common side effects include gastrointestinal issues such as stomach pain or abdominal pain, diarrhea, nausea, constipation, and vomiting. These side effects are most common after first starting Ozempic or increasing the dose, and they can be managed with diet and lifestyle changes. Excessive weight loss can also occur in some individuals and should be monitored closely.

Other side effects are much more rare, such as pancreatitis (inflammation of the pancreas), changes in vision, hypoglycemia (low blood sugar), kidney problems, severe stomach pain and associated problems, gallbladder problems, and thyroid tumors, which are a potential but rare risk associated with Ozempic.

For these reasons, some people should not take Ozempic, such as those with a personal or family history of pancreas problems, diabetic retinopathy, severe stomach problems, or women who are currently pregnant or plan to become pregnant. Before starting Ozempic, it’s important to go over your medical history carefully with your doctor to ensure the medication won’t worsen any preexisting conditions. Regular blood tests may be recommended to monitor for complications such as pancreatitis or thyroid issues.

Patients should be aware of all potential adverse effects and discuss any concerns with their doctor.

Can Ozempic Cause Joint Pain? 3 Possible Causes

Joint pain is not one of the side effects included on the warnings for Ozempic, so is it even possible for Ozempic or semaglutide to cause joint pain?

In clinical trials for Ozempic, participants did not report experiencing joint pain. And, in fact, GLP-1 receptor agonists like semaglutide have been shown to have anti-inflammatory properties that could be helpful for people with osteoarthritis.

So if Ozempic doesn’t cause joint pain, then why do some people taking Ozempic experience joint pain? Currently, professionals theorize that people taking Ozempic may be mistaking the real cause of their joint pain, which is often either autoimmune disorders, other medications, or other health conditions. Chronic pain conditions or autoimmune diseases, such as lupus, may be mistaken for medication side effects. It is important to consult a healthcare professional for an accurate diagnosis and appropriate management. Clinical outcomes from studies on Ozempic and joint pain are still being evaluated, and ongoing research continues to assess these effects.

Autoimmune Disorders

Autoimmune diseases and conditions, such as rheumatoid arthritis and psoriatic arthritis, which both affect the joints and cause pain, may be more likely to experience joint pain while taking Ozempic and mistakenly think the Ozempic is the cause rather than a natural flare-up.

If you’re taking Ozempic and experience new joint pain, swelling, or redness, it’s a good idea to bring it up with your doctor, as they can potentially be a sign of a new arthritis condition.

Other Medications

Joint pain is a fairly common side effect among other medications, and you may not be aware of it. Some common medications that list joint pain as a side effect include

• DDP-4 inhibitors
• Statins used to treat high cholesterol
• Bisphosphonates that treat osteoporosis
• Premarin, which treats menopause symptoms
• Carvedilol, which treats high blood pressure

If you’re taking any of these medications and are experiencing joint pain, it’s more likely that they’re the cause of the pain than Ozempic is.

Other Health Conditions

If you have any of these health conditions, they may be the cause of joint pain you are experiencing:

• Gout
• Tendonitis (inflammation of tendons)
• Fibromyalgia (chronic condition that causes pain all over the body)
• Bone erosion
• Ligament damage
• Bursitis (inflammation of the fluid sac between the bones of a joint)
• Muscle weakness
• Joint dislocation
• Bone cancer
• Avascular necrosis (death of bone tissue)

5 Tips for Managing Joint Pain

If you encounter joint pain, there are methods you can use to help relieve joint pain. The following methods are aimed at pain relief and relieving joint pain.

1. Over-the-Counter Medications

The first defense against pain for most people is OTC pain relievers such as ibuprofen or acetaminophen. These medicines can be extremely useful for helping manage joint pain throughout the day, and some brands even make versions that are specifically intended for people with arthritis.

2. Heating and Cooling

Another popular way to help relieve joint pain is by using heating pads or ice packs to reduce pain. Warmth can help relax muscles to reduce inflammation, while ice packs can numb pain and reduce swelling. When using heat or cold packs, make sure to use them in 15- to 20-minute rotations, and always wrap ice packs in a cloth. Do not leave an ice pack directly against your skin for prolonged periods of time.

3. Physical Therapy

If the joint or muscle pain you’re feeling is really bad, you may want to pursue physical therapy to help relieve it. Physical therapy can help improve muscle health, and incorporating regular physical activity is important for maintaining joint and muscle function. You can also perform physical therapy at home by following exercises that strengthen muscles around the sore joint. You can also improve your flexibility by doing stretches that focus on your range of motion.

4. Surgery

In cases where joint pain can’t be managed by other means, you may want to pursue surgery to repair or replace the affected joint. Joint surgery is typically a last resort option, but it can also be the most effective.

5. Weight Loss

A famous study found that for every pound you lose, you reduce the pressure on your knees by four pounds, which is a huge difference that can drastically affect your quality of life. Losing weight is especially beneficial for overweight and obese adults with knee osteoarthritis, as it can significantly reduce pain and improve mobility.

Studies have shown that overweight and obese adults who lose weight experience less pain and improved mobility. While the same can’t be said for every joint in the body, it’s well known that weight loss still helps relieve pressure, and other studies have shown that people who are able to lose 20% of their starting weight experienced roughly 25% less pain, improved knee function, and improved quality of life compared to those who only lost 5 to 10% of their original body weight.

Reducing extra weight helps decrease knee joint loads and alleviates pain in weight bearing joints, especially weight bearing ones like the hips and knees. An intensive diet and dietary adjustments, along with healthy eating, can support weight loss and improve joint health. Carrying extra weight puts extra stress on joints, increasing the risk of osteoarthritis and joint pain.

Understanding the Link Between Ozempic and Joint Pain

Although joint pain is not listed as a known side effect of Ozempic, it’s still something you report while taking the medication. Often, the true cause of the discomfort lies elsewhere, whether it’s an undiagnosed autoimmune condition, interactions with other medications, or a pre-existing health issue. Regardless of the source, joint pain can interfere with your quality of life and deserves proper attention.

If you’re currently on Ozempic or considering it, and you’re unsure how it may affect your body, especially if you’re already dealing with joint issues, don’t navigate it alone. A registered dietitian can help you understand how medications like Ozempic fit into your overall health plan, including strategies to manage potential side effects like inflammation or pain. Weight management is a key component in reducing joint pain and improving overall health for people taking Ozempic.

Want expert support? Sign up today to talk to a registered dietitian at no cost to you and get personalized guidance on managing Ozempic, joint pain, and your long-term health goal!

The Role of Healthcare Professionals in Managing Ozempic Joint Pain

Healthcare professionals play a crucial role in helping patients manage joint and muscle pain, especially when it may be associated with taking Ozempic. They are trained to evaluate the underlying causes of pain, whether it’s related to medication, an existing medical condition, or another factor. By thoroughly assessing your symptoms and medical history, healthcare providers can recommend the most effective treatment options and monitor your progress over time.

A personalized treatment plan developed with your healthcare provider can address your unique needs, taking into account your lifestyle, body weight, and any other medications you may be using. This collaborative approach ensures that you receive the right support to manage joint and muscle pain, prevent severe joint pain, and improve your overall quality of life. Healthcare professionals can also help you weigh the potential risks and benefits of Ozempic, empowering you to make informed decisions about your treatment and long-term health.

Healthcare Provider Guidance

When it comes to managing joint and muscle pain while taking Ozempic, healthcare providers are your best resource for practical and effective guidance. They may suggest lifestyle adjustments such as exercising regularly, maintaining a healthy weight, and following a balanced diet to help alleviate pain and support joint health. In some cases, your provider might recommend medications like anti-inflammatory drugs to manage pain and reduce inflammation.

If your pain persists or becomes severe, your healthcare provider can refer you to a physical therapist or other specialists for additional support and targeted treatment. By following the advice of your healthcare team, you can take proactive steps to relieve joint pain, minimize discomfort while taking Ozempic, and reduce your risk of developing severe joint pain. Open communication with your provider ensures that your treatment plan is always tailored to your needs and that you receive the best possible care.

Frequently Asked Questions: Joint Pain and Ozempic

Have Clinical Trials Shown a Link Between Ozempic and Joint Pain?

Clinical trials for Ozempic did not show a clear link to arthritis or joint pain. In fact, in one analysis, joint pain was reported less frequently in people taking Ozempic than in those on a placebo.

What Should I Do if I Experience Joint Pain While Taking Ozempic?

If you notice new or worsening joint pain, here are steps you can take:

1. Bring it up with your healthcare provider to rule out other causes — such as arthritis, injury, or medication interactions
2. Consider physical therapy, joint-focused stretching, or low-impact exercise
3. Ensure adequate hydration, protein, and nutrient intake
4. Evaluate whether any other medications you take might contribute to joint symptoms
5. In rare cases, your provider might consider adjusting your dose or exploring alternative medications

Can Ozempic Help Reduce Joint Pain Rather than Cause It?

Yes, especially for people with osteoarthritis, weight loss can reduce stress on joints, improve movement, and lower inflammation. A study of individuals with knee osteoarthritis showed that semaglutide use (same active ingredient as Ozempic) led to significant pain reduction.

Work With a Dietitian to Improve Your Ozempic Outcomes

While joint and muscle pain are not commonly reported side effects of Ozempic, they can still occur for some individuals. Understanding the potential causes of joint and muscle pain, including changes in body weight and underlying health conditions, is essential for effective management.

Managing joint and muscle discomfort while on Ozempic starts with understanding how your body responds to change. At Dietitian Live, our registered dietitians provide personalized support that addresses nutrition, lifestyle, and the mindset shifts that drive lasting results.

Book your free first session and get the guidance you need to feel your best throughout your treatment.