Over-The-Counter Diabetes Medicine: Glucose Tablets & Other Medications

Yvette Vallejo

Medically Reviewed By: Yvette Vallejo, PSM, RD, LD

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Written By: Shelby Leith, RPhT

Published: August 15, 2025

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Updated: August 15, 2025

OTC Diabetes Medications

If you are living with diabetes, you might have wondered whether there are ways to manage your blood sugar without always having to rely on a prescription. While most of the best diabetes medications still require the guidance of a doctor, over the counter diabetes medicine may help in some situations. Up next, we will take a look at what options are available, how they work, and what to keep in mind so that you can make the safest and most informed choices for your health.

Key Takeaways

  • Most over the counter options for diabetes include items like glucose tablets, supplements, and certain types of otc insulin that can be purchased without a prescription in some states.
  • These tools are not meant to replace prescription insulin or your regular diabetes medications, but they may help manage mild symptoms such as low blood glucose.
  • It’s important to remember that dosages, potential interactions with other medications, and how these products fit into your meals can all affect how safe they are and how well they work for you.
  • A registered diabetes dietitian can help you decide which options are the best for you.

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What is Diabetes?

Diabetes affects how your body uses insulin, which is the hormone responsible for helping your cells take in blood glucose for energy. If this process doesn’t work properly, glucose builds up in your bloodstream, leading to long-term health concerns if it’s not managed properly.

There are two main types of diabetes. Type 1 diabetes happens when your body doesn’t make insulin at all, while type 2 diabetes means your body still makes insulin but doesn’t use it properly. Both types require different treatment plans, but managing diabetes always comes down to understanding how food, activity, and medication affect your blood glucose levels throughout the day.

Can You Treat Diabetes Without a Prescription?

All diabetes treatments (especially those that involve long-term blood glucose control) require a prescription from your doctor. This is especially true for anyone living with type 1 diabetes, where daily insulin is essential and can’t be replaced by nonprescription products. That being said, there are a few over the counter medicines that can help with specific situations, like treating mildly low blood sugar or filling a short-term gap when there is a delay to accessing your regular treatment.

You can find these products at your local pharmacy, but it’s important to remember that using them without guidance from a healthcare practitioner may carry some risk.

10 Types of Over the Counter Diabetes Medicine Options

Prescription medications are one of the best options for long-term blood sugar control. However, there are some over the counter products that can help you manage specific symptoms or can help with your treatment plan.

1. Glucose Tablets

Glucose tablets are a fast way to treat low blood glucose. They contain a carefully measured amount of sugar and are designed to raise your blood glucose levels quickly during a hypoglycemic episode. They are small, easy to carry with you, and are great for keeping in your bag or car in case of emergencies.

2. Glucose Gels and Pills

If you find tablets hard to chew or that they absorb slowly, glucose gels and soft glucose pills are a quick alternative. These products are made for fast digestion and are especially helpful when your blood glucose levels drop suddenly and you need a rapid energy boost.

3. Human OTC Nonprescription Insulin (e.g., Walmart ReliOn)

In most states, you can buy OTC insulin, a form of nonprescription insulin, like ReliOn without a prescription. This nonprescription insulin is a short-acting form of insulin that can be used in urgent situations or while you’re waiting to refill your prescribed insulin products. You can find it at select pharmacy counters, but it’s important to use it under medical supervision. OTC options are not tailored to your individual needs and may put you at high risk if they aren’t the right dose or are used long term.

4. Supplements Like Cinnamon, Chromium, and Berberine

Several supplements are marketed as tools to help with blood sugar control. Natural ingredients like cinnamon, chromium, and berberine may be effective, although results vary. While these may have some benefits, they are not a substitute for medication. They can sometimes improve insulin sensitivity, reduce sugar spikes after eating, or potentially help you manage prediabetes. However, some supplements can cause side effects that should be considered carefully. Berberine, for example, can cause gastrointestinal issues like diarrhea, constipation, nausea, and gas. It can sometimes also cause low blood pressure and rashes in rare cases. You should always speak with your doctor when trying to manage your diabetes with supplements.

5. Acarbose and Alpha-Glucosidase Inhibitors (Available in Some Markets)

Though usually prescribed, acarbose and similar medications that slow the breakdown of carbs are sometimes found over the counter in international markets. These drugs help limit the spike in sugar after meals by slowing down how fast carbohydrates are absorbed.

6. Magnesium and Vitamin D

Certain supplements like magnesium and vitamin D may help improve your insulin response and blood sugar regulation. These nutrients help the body use insulin more effectively and can sometimes reduce inflammation. Because deficiencies in these nutrients are common, especially among people with diabetes, adding them into your daily routine may give you some extra support, but you should always discuss it with a healthcare professional first.

7. Fiber Supplements (Psyllium, Inulin)

If you’re looking to manage blood sugar, fiber supplements like psyllium or inulin can help slow digestion and reduce a sharp rise in glucose after eating. These work well when they are taken before or with meals and may help your body absorb carbohydrates more gradually. They’re available in powders, capsules, or even gummies, and can be an easy way to improve your blood sugar and stay regular at the same time, however, it’s important to stay hydrated when taking supplements, because water can help you metabolize supplements more effectively.

8. Apple Cider Vinegar Tablets

Apple cider vinegar tablets are a popular supplement that might give you some subtle benefits for fasting blood glucose levels in some people. How effective they are is unclear, but some small studies show that apple cider vinegar may help slow the release of sugar into the bloodstream after meals. While it’s not a replacement for medication, it can be considered as an add-on to your routine.

9. OTC Pain Relievers for Diabetics

For patients that are dealing with both diabetes and chronic pain, choosing the right pain relief medication matters. Acetaminophen (Tylenol) is often preferred over NSAIDs like ibuprofen, especially for people with kidney disease, since it poses less risk to kidney function. If you are unsure which product is safest, it’s always best to check with your doctor or pharmacist.

10. Sugar-Free Electrolyte Drinks or Rehydration Powders

During times when your blood sugar is high or you’re dealing with mild dehydration, sugar-free electrolyte drinks or powders can help replenish your fluid levels. These drinks can give you a boost of energy without added sugar and are a great option if you’re experiencing fatigue, nausea, or vomiting. Look for options that are labeled as “diabetic-friendly” or “no added sugar,” and always read the label carefully to make sure they don’t interfere with your blood sugar goals.

Do OTC Products Work the Same as Prescription Medications?

While over the counter products can be very helpful in certain situations, they are not designed to replace your prescription medications. Prescription medications go through much more extensive testing to ensure that they are safe for long-term use and will be effective for managing your conditions.

They are also tailored to your specific needs by your healthcare provider who will ensure that you always get the right dose. OTC options, like glucose tablets or supplements, are meant to help manage symptoms or to give you short-term relief during an emergency. It’s always highly recommended that you talk to your doctor or dietitian first, before using any nonprescription product alongside your regular treatment plan.

Making Safe Choices with Over the Counter Diabetes Medicine

When you’re thinking about adding over the counter diabetes medicine to your routine, it’s important to make sure that you’re using the right products in the right way for you. That means understanding the proper dosage, watching for any potential interactions with your other medications, and knowing when to take them with meals or during low blood sugar events. Even though these products are available without a prescription, using them without the right guidance can be risky. This is where a registered dietitian can give you the help you need.

A dietitian can explain how different OTC products work, when you might still need a prescription, and how to make some small adjustments to your diet to be better able to meet your blood sugar goals. They also help you build a plan that fits into your lifestyle, whether your goal is a more balanced diet, better weight management, or long-term diabetes control. At DietitianLive, you can meet remotely with licensed experts, often with $0 out-of-pocket cost, depending on your insurance.

If you’re looking for answers and a plan that works for you, contact DietitianLive today. Talk to one of our dietitians, ask questions, and feel confident knowing that you’re making safer, more informed decisions about your health goals and your diabetes medications.

Frequently Asked Questions

What is type 2 diabetes?

Type 2 diabetes is a chronic condition where your body still makes insulin but becomes sensitive to it over time, meaning it does not use it properly. This leads to higher blood glucose levels, which can increase your risk for long-term complications if not well managed. Many patients manage type 2 diabetes through a combination of nutrition, exercise, and diabetes medications. Some may eventually require insulin products, especially if other medications no longer meet their needs.

Why do doctors no longer recommend metformin?

While metformin is still commonly prescribed for diabetes, some patients may not be ideal candidates if they have kidney issues or cannot tolerate certain common side effects like stomach upset or fatigue. In some cases, newer diabetes medications may give additional benefits such as weight loss or cardiovascular protection. It’s important to talk to your doctor to review the latest research, discuss your treatment goals, and determine if a change in drug or dose is needed for your safety and long-term results.

What is the fastest medication to lower blood sugar?

The fastest-acting option for rapidly reducing blood glucose is typically fast-acting insulin products, which begin working within minutes and are used to correct high levels quickly. However, this drug must be prescribed and carefully monitored. Using the wrong dose can result in low blood glucose or other side effects.

Are glucose tablets healthier than sugar?

Glucose tablets are not necessarily healthier than table sugar, but they are more predictable in how they raise blood glucose, which makes them a safer choice during a low blood glucose episode. Unlike foods like candy or juice, glucose tablets contain no fat or fiber that could slow absorption, and their form is specifically designed for quick action. These tablets can be purchased at any pharmacy, and they are recommended by healthcare professionals for their effectiveness.

What happens if a non-diabetic takes glucose tablets?

If someone without diabetes takes glucose tablets, it may cause a temporary rise in blood glucose without any medical benefit. While a small dose is unlikely to cause harm, regular use without a medical need may create unnecessary stress on the body’s insulin system. Misusing any drug, including over the counter medications, can carry risk, especially for those who are sensitive to changes in blood sugar. If you are unsure whether you should use glucose tablets, talk to a pharmacist or doctor. These products are intended to provide assistance for treating low blood glucose, not to boost energy or replace meals.

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